| Name | Difficulty | Description | Available from | Boss Rule |
|---|---|---|---|---|
| Artifact | + | Start with 1 random upgrade | Always | |
| Channeling Pain | + | Gain 1 mana for every 25% Health missing when entering card phase | Always | |
| Companion Curse | - | Whenever your companion dies, you take 30 damage. | Always | |
| Curse of Excess | Draw an additional card at the beginning of each arena. If you have more than 5 cards when the arena begins, you will take 30 damage. | Always | ||
| Endless Supplies | + | When you play 2 cards in one card phase, gain a random consumable card. | Always | |
| Fluctuations | Cards randomly cost +1 or -1 mana. | Always | Yes | |
| Gotta Go Fast!! | + | Collecting point pickups gives you +1 stackable Movement Speed for 8 seconds. | Always | |
| Heat Wave | - | Fiery projectiles fly across the arena. A lot of them. 20 Damage on impact. | Always | Yes |
| Level Up | + | Start with 2 random class specific upgrades. | Always | |
| Magnetic Weapon | - | Your attacks pull victims towards you | Always | |
| Magnificence | You start at 50% health. Draw 1 card each time you end an arena at full Health. | Always | ||
| Puff Party | + | Gain a random puff card each card phase | Always | Yes |
| Quick Minions | - | All starting enemies gain +2 Movement Speed | Always | Yes |
| Rebel Cleavers | + | Start with 2 allied Cleavers each round. | Always | |
| Rebel Musketeer | + | Start with an allied musketeer each round. | Always | |
| Rebel Whirly Rats | + | Start with 2 allied Whirly Rats each round. | Always | |
| Slippery Cards | Each arena: Discard the leftmost card from your hand and draw another one. | Always | Yes | |
| Supplies: Chaotic Illumination | + | Start with the Chaotic Illumination card played | Always | |
| Supplies: Lightning Rod | + | Start with the Lightning Rod card played. | Always | |
| Supplies: The Aeselator | + | Start with The Aeselator card played. | Always | |
| Two Toys | + | Start with two random consumables. | Always | |
| Patchwork | - | All starting minions gain +40 Health. | Crucible, chamber 2 | |
| Short Battles | + | Short but intense! Only 4 arenas before meeting the boss. Mana gain doubled. | Crucible, chamber 2 | |
| Supporting The Winning Team | - | When damaged, your companion becomes evil until you kill 3 enemies. +50% companion Health. | Crucible, chamber 2 | |
| Chain Reaction | +150% summoning portal efficiency. Your attacks infect enemies to explode for 15 damage to other enemies on death. | Frontline | ||
| Copy Machine | Removes half of your deck and replaces it with cards from the other half. | Frontline | Yes | |
| Delicate Summons | Summons take double damage. +150% summoning portal efficiency. | Frontline | Yes | |
| Desperate Survival | +400% summoning portal efficiency. Enemies start aggressive. After 30 seconds all enemies die. | Frontline | ||
| Laser Leash | + | A beam connects you and your companion, dealing 8 damage to enemies it touches. | Frontline | |
| Left and Right | + | Playing a card increases the mana cost of all cards to the right by 1 and decreases all cards to the left by 1. | Frontline | Yes |
| Mana Banks | - | You will only get 3 mana every round, but mana is no longer reset between arenas. | Frontline | |
| Necromancer | + | Kill: Resurrect enemy as ally. You take +100% Damage. | Frontline | |
| Raff's Son | - | Summons Raff's Son, a worthless fighter. Anyone killing him is punished for 50 unavoidable Damage. | Frontline | |
| Rage Fest | The lower health anything gets the more damage it deals, both you and the enemies. | Crucible, chamber 2 | ||
| Side Effects: Consumables | + | Consumable card played: -1 Upgrade mana cost, +1 Spell mana cost. Also affects future cards. | Frontline | |
| Side Effects: Spells | - | Spell card played: -1 Consumable mana cost, +1 Upgrade mana cost. Also affects future cards. | Frontline | |
| Side Effects: Upgrades | + | Upgrade card played: -1 Spell mana cost, +1 Consumable mana cost. Also affects future cards. | Frontline | |
| Soul Break | - | Damage received reduces max health. 50% damage reduction. | Frontline | |
| Soul Link | + | A beam connects you and your companion, dealing 8 damage to enemies it touches. | Frontline | Yes |
| Stayin' Alive | - | Lose 10 health every 5 seconds. Kill: Heal 4. | Frontline | |
| Supplies: Masochistic Blade | Start with the Masochistic Blade card played. | Frontline | ||
| Supplies: The Real Deal | + | Start with the The Real Deal card played. | Frontline | |
| Unstable Mana | +1 mana each card phase. Take 10 Damage per mana not spent. | Frontline | ||
| Sharing is Caring | + | Split all damage you take with your companion. |
Boss rules are those that can also occur in the unavoidable chamber boss battles.